KMID : 0614620200750010023
|
|
Korean Journal of Gastroenterology 2020 Volume.75 No. 1 p.23 ~ p.28
|
|
Influencing Factors on Lactulose Breath Test Results
|
|
Kim Jin-Won
Park Seon-Young Chung Jin-Ook Cho Hyun-A Kim Dong-Hyun Yoon Jae-Hyun Park Chang-Hwan Kim Hyun-Soo Choi Sung-Kyu Rew Jong-Sun
|
|
Abstract
|
|
|
Background/Aims: This study aimed to identify the demographic and clinical factors associated with positive breath-test results and to assess the relationship between hydrogen and methane production in patients with suspected irritable bowel syndrome (IBS).
Methods: The demographic and clinical factors of 268 patients with suspected IBS, who had undergone a lactulose breath test, were analyzed.
Results: Of 268 patients included in this study, 143 (53.4%) were females. The median age and BMI of the patients was 58.0 years (range, 18.0-80.0 years) and 22.5 kg/m2 (range, 14.4-34.3 kg/m2), respectively. A weak positive correlation was observed between the BMI and baseline hydrogen level (rho=0.134, p=0.031). Women were significantly more likely to show a ¡Ã20 ppm increase in hydrogen within 90 min (early hydrogen increase, p=0.049), a ¡Ã10 ppm increase in methane within 90 min (early methane increase, p=0.001), and a ¡Ã10 ppm increase in methane between 90 min and 180 min (late methane increase, p=0.002) compared to men. The baseline hydrogen level was related to the baseline methane level (rho=0.592, p<0.001) and the maximal hydrogen level within 90 min was related to maximal methane level within 90 min (rho=0.721, p<0.001). Patients with an early hydrogen increase (43.8%) were more likely to show a positive result for an early methane increase compared to patients without an early increase in hydrogen (0%, p<0.001).
Conclusions: Women were associated with high rates of positive lactulose breath-test results. In addition, methane production was correlated with hydrogen production.
|
|
KEYWORD
|
|
Lactulose, Breath tests, Irritable bowel syndrome, Difference, sex
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|